“The Lord said to the Adversary, ‘Have you noticed My servant Job? There is no one like him on earth, a blameless and upright man who fears God and shuns evil. He still keeps his integrity; so you have incited Me against him to destroy him for no good reason.”
The Adversary answered the Lord, ‘Skin for skin —all that a man has he will give up for his life. But lay a hand on his bones and his flesh, and he will surely blaspheme You to your face.”
So the Lord said to the Adversary, “See, he is in your power; only spare his life.” The Adversary departed from the presence of the Lord and inflicted a serious inflammation on Job from the sole of his foot to the crown of his head. Job 2/3-7 Tanakh JPS 1985
But the Lord chose to crush him by disease, That, if he made himself an offering for guilt, he might see offspring and have long life, And that through him the Lord’s purpose might prosper. Out of his anguish he shall see it; He shall enjoy it to the full through his devotion. Isaiah 53/10 Tanakh JPS 1985
In the book of Job G-d tests the devotion of a righteous man who G-d knows will think that G-d owes him an explanation for his suffering by indirectly crushing him with disease. In the book of Isaiah G-d creates the devotion of a sinner by directly crushing him with disease and accepting his agreement to make himself an offering for guilt.